Platelet-rich plasma injection in the olfactory clefts of COVID-19 patients with long-term olfactory dysfunctionArticle Published on 2023-05-012023-07-11 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID19(2023년), [키워드] Anosmia coronavirus COVID-19 Hyposmia olfactory otolaryngology platelet-rich plasma recovery rhinology SARS-CoV-2 Smell. [DOI] 10.1007/s00405-022-07788-8 PMC 바로가기
Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patientsArticle Published on 2022-12-072023-07-10 Journal: Neuron [Category] COVID19(2023년), [키워드] blood-brain barrier brain parenchyma coronavirus COVID-19 Delta frontal lobe glia limitans perivascularis leptomeninges neuroinvasion neurotropism olfactory olfactory bulb olfactory sensory neuron omicron perineurial olfactory nerve fibroblast. RNAscope SARS-CoV-2 Virchow-Robin space [DOI] 10.1016/j.neuron.2022.11.007 PMC 바로가기
The study of olfactory dysfunction in SARS-CoV-2 variantsArticle Published on 2022-11-012022-11-16 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID19(2023년), SARS, 변종, [키워드] Abstract COVID-19 Head–neck surgery Olfaction olfactory olfactory dysfunction otolaryngology SARS-CoV-2 SARS-CoV-2 variant Smell Variant. [DOI] 10.1007/s00405-022-07548-8 PMC 바로가기
Prevalence of acute olfactory dysfunction differs between variants of SARS-CoV-2-results from chemosensitive testing in wild type, VOC alpha (B.1.1.7) and VOC delta (B.1617.2)Article Published on 2022-11-012022-11-16 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID19(2023년), SARS, 변종, [키워드] acute SARS-CoV-2 infection Alpha B.1.1.7 blinded COVID-19 dysfunction Hyposmia impairment Next-generation sequencing Olfaction olfactory olfactory dysfunction olfactory function Patient Prevalence Prospective Study quantitative real-time PCR SARS-CoV-2 significant difference Smell Smell. subsequent symptoms of COVID-19 variant variants virus virus variant VoC wild type [DOI] 10.1007/s00405-022-07431-6 PMC 바로가기
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19Article Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome astrocytes Brain cellular mechanism CNS coronavirus coronavirus disease COVID-19 CP: Microbiology CP: Neuroscience Diabetic exacerbated High-resolution induce infect Infection initial investigated macaque microglia Microscopy modulated molecular Neuroinflammation Neurological complication Neurological complications Neuron neuronal neurotropism NHP non-human primate model olfactory patients plethora provide reducing Region rhesus rhesus. robust SARS-CoV-2 systemic inflammatory response triggered [DOI] 10.1016/j.celrep.2022.111573 PMC 바로가기
Evidence for the spread of SARS-CoV-2 and olfactory cell lineage impairment in close-contact infection Syrian hamster modelsArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition Administered assigned caused Cell cells changes in close contact complication of COVID-19 Contact days post infection detectable examined group groups hamster highest immature Impact impairment indicated Infection Lineage lung lung damage lung; nose occurred olfactory Olfactory epithelium olfactory receptor cells ORN ORNs pathogenesis of COVID-19 patients with COVID-19 receptor SARS-CoV-2 short-term cohabitation. significantly Spread subsequent tissue tissue damage transmitted uninfected unique Viral load viral presence Viral transmission virus [DOI] 10.3389/fcimb.2022.1019723 PMC 바로가기
SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytesArticle Published on 2022-10-012022-11-16 Journal: Journal of neurochemistry [Category] COVID19(2023년), SARS, 치료기술, [키워드] Alpha Alter Astrocyte astrocytes blockade Brain carbon metabolism cause change Cognitive impairment Confusion COVID-19 death evaluated Evidence evidenced Glucose Glutamine Glycolysis hamsters Hyperactivation Immunopathogenesis Impact in vitro in vivo Inflammatory response intranasally ketoglutarate Lung disease memory metabolomics neurological Neurological diseases neurological impairment Neuropathology neurotransmitter olfactory Protein proteomics proteomics. pyruvate reduction Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 synaptic Transmission viral replication [DOI] 10.1111/jnc.15679 PMC 바로가기
Coronavirus disease 2019 (COVID-19)-related smell and taste impairment with widespread diffusion of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Omicron variantArticle Published on 2022-10-012022-11-16 Journal: International forum of allergy & rhinology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Characteristics chemosensory clinical presentation coronavirus disease Coronavirus disease 2019 COVID-19 diffusion dropped dysfunction evaluated impairment Infection Mild-to-moderate olfactory olfactory dysfunction omicron Omicron variant outcomes Patient patients positive Prevalence Prospective reported SARS-CoV-2 sense of smell sense of taste severity significantly significantly lower Smell study cohort subject taste dysfunction Taste. variant widespread [DOI] 10.1002/alr.22995 PMC 바로가기
Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads studyArticle Published on 2022-09-292022-11-16 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] acquisition Analysis ASL assessment automatically Brain brain phenotype Cambridge collected college comparable Complication complications of COVID-19 component correlation COVID dataset defined diagnostic diffusion Effect feasibility File functional General Electric healthy imaging indicated King limitation linear London Measures MRI Neuropsychiatric olfactory over Oxford participant Participants pathogenic mechanisms Patient protocol Quantitative reduced reliability repeated Research SARS-CoV-2 SARS-COV-2 infection sequence Siemen susceptibility UK biobank UKB Variability [DOI] 10.1371/journal.pone.0273704 PMC 바로가기
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recoveryArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome affected animal model change coronavirus correlated COVID COVID-19 demonstrated detectable exceeded hamster highlight host response Human IAV individual Infection Infectious virus influenza A virus Injury interferon response kidney lack lung mechanism molecular mechanism olfactory Olfactory epithelium PASC pathology Perturbation Proinflammatory cytokine response Result SARS-CoV-2 SARS-COV-2 infection sustained T cell activation tissue transcriptional change unique viral clearance [DOI] 10.1126/scitranslmed.abq3059 PMC 바로가기